The Malaysian Airlines flight was en route to Kuala Lumpur from Beijing in 2014 when it disappeared with 239 passengers on board.
Since then, numerous search operations have been launched, with little success.
And now James Cameron, who directed Titanic, has said he is not surprised that the jet has not been uncovered.
“An anomaly the size of an airframe won’t show up on the data that we have now,” he told news.com.au.
"We know more about the surface of Mars or the Moon than we do our deepest oceans."
The 63-year-old then revealed that he would be keen to help in the search.
He added:"The equipment I’ve designed is specifically designed to explore deep and local to an already identified site of scientific interest.
“Once they find a site, I’m a specialist in wreck sites, you give me a wreck site and I know how to explore it, I know how to map it, I know how to use small robotics to go in and analyse it and do the wreck forensics on it.
“I’m not saying that’s something that would excite me, going to an aircraft site — personally I’m more interested in ships.”
His research into the Titanic and German battleship the Bismarck, helped reveal new clues about the fate of the ships and how they sunk.
James – also known for his work with Avatar and the Terminator franchise –detailed that despite searching thousands of square kilometres of deep ocean, the missing Malaysia Airlines flight could be anywhere.
“The ocean is huge mate, people really have no idea," he added.
"We have this sense that everything is explored and we’ve got it all wrapped up and we’ve got our satellites, but the second you go below the water it’s a vast unknown.
“We’re talking hundreds of thousands of square miles of ocean, most of it unmapped. We don’t know what that bottom looks like and it will take us decades to survey it all.
“Now if one were to mount an enormous search across the entire western Pacific and Indian Ocean we’d learn an awful lot, it’d be great.
"I’d love for somebody to throw a few billion [dollars] at that. We’d learn an awful lot about the deep ocean.
“It’s human arrogance to think we know so much about the Earth.”
The search for the missing Boeing 777 is said to be the largest in aviation history.
The four-year manhunt had accumulated a cost of more than £150 million, but just this morning the Malaysian Prime Minister vowed to continue the investigation.
